Expression of cyclins and cyclin-dependent kinases in smooth muscle tumors of the uterus
نویسندگان
چکیده
منابع مشابه
Smooth Muscle Tumors of the Uterus Pathology
The diagnosis of uterine leiomyosarcoma is usually straightforward since most clinically malignant smooth muscle tumors of the uterus show the microscopic constellation of hypercellularity, severe nuclear atypia, and high mitotic rate generally exceeding 15 mitotic figures per 10 high-power-fields (MF/10 HPF). Frequently, one or more supportive clinicopathologic features such as perior postmeno...
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Androgen induces prostate cell proliferation in the castrated rat. We hypothesized that G1 cyclins, cyclin-dependent kinases (cdk), and cdk inhibitors mediate this cellular response to mitogenic signals. In this study, induction of cyclins D1, D2, D3, E, and cdks 2, 4, and 6 expression was observed at various time points during testosterone replacement in the ventral prostate of castrated rats....
متن کاملExpression of cyclins and cyclin dependent kinases in human benign and malignant melanocytic lesions.
AIMS The regulation of cell proliferation is a key event in normal development, pathophysiological responses to injury, and tumorigenesis. The orderly progression of cells through the cell cycle depends on a finely tuned balance between the concentrations of activated cyclins and cyclin dependent kinases. This study was undertaken to compare the expression of cell cycle regulators in benign and...
متن کاملCyclins and cyclin-dependent kinases: a biochemical view.
Cyclins are the activating partners of a highly conserved family of protein kinases, the cyclin-dependent kinases (CDKs). A number of diverse cyclins and CDKs are now known, many of which play important roles in the regulation of the eukaryotic cell cycle. However, it has recently become clear that the cyclin-CDK motif is used by the cell to control processes separate from the cell cycle, such ...
متن کاملLiving with or without cyclins and cyclin-dependent kinases.
Entry into, progression through, and exit from the G1 phase of the mammalian cell cycle in response to extracellular mitogenic cues are presumed to be governed by cyclin-dependent kinases (Cdks) regulated by the D-type and E-type cyclins. Studies performed over more than a decade have supported the view that these holoenzymes are important, if not required, for these processes. However, recent ...
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ژورنال
عنوان ژورنال: International Journal of Cancer
سال: 1999
ISSN: 0020-7136,1097-0215
DOI: 10.1002/(sici)1097-0215(19990621)84:3<244::aid-ijc8>3.0.co;2-2